Publications from 1991-Present

Note: PDF reprints should be accessed only from JHU/JHMI to avoid copyright infringement. Some journals distribute PDFs for free, but others require online subscription.

Weinberg, S., S. Iravanian and L. Tung. Representation of collective electrical behavior of cardiac cell sheets. Biophys J (in press), 2008.

Zhang, Y., R. B. Sekar, A. D. McCulloch and L. Tung. Cell cultures a models of cardiac mechanoelectric feedback. Prog Biophys Mol Biol (in press), 2008.

Cysyk, J. and L. Tung. Electric field perturbations of spiral waves attached to millimeter-size obstacles. Biophys J 94:1533-1541, 2008. Abstract.

Lin, J. W., L. Garber, Y. R. Qi, M. G. Chang, J. Cysyk and L. Tung. Region of slowed conduction acts as core for spiral wave reentry in cardiac cell monolayers. Am J Physiol Circ Physiol 294:H58-H65, 2008. Abstract.

Tung, L. and J. Cysyk. Imaging fibrillation/defibrillation in a dish. J Electrocardiol 40:S62-S65, 2007. Abstract.

Bursac, N., Y. Loo, K. Leong and L. Tung. Novel anisotropic engineered cardiac tissues: studies of electrical propagation. Biochem Biophys Res Comm 361:847-853, 2007. Abstract.

Sekar, R. B., E. Kizana, R. R. Smith, A. S. Barth, Y. Zhang, E. Marban and L. Tung. Lentiviral vector mediated expression of GFP or Kir2.1 alters the electrophysiology of neonatal rat ventricular myocytes without inducing cytotoxicity. Am J Physiol 293:H2757-H2770, 2007. Abstract.

Kizana, E., C. Chang, E. Cingolani, G. A. Ramirez-Correa, R. B. Sekar, M. R. Abraham, S. L. Ginn, L. Tung, I. E. Alexander and E. Marban. Gene transfer of connexin43 mutants attenuates coupling in cardiomyocytes: novel basis for modulation of cardiac conduction by gene therapy. Circ Res 100:1597-604, 2007. Abstract.

Tung, L. and Zhang, Y. Optical imaging of arrhythmias in tissue culture. J Electrocardiol 39:S2-S6, 2006. Abstract.

Lim, Z. Y., B. Maskara, F. Aguel, R. Emokpae, and L. Tung. Spiral wave attachment to millimeter-size obstacles. Circ 114:2113-2121, 2006. Abstract.

Sathaye, A., N. Bursac, S. Sheehy, and L. Tung. Electrical pacing counteracts instrinsic shortening of action potential duration of neonatal rat ventricular cells in culture. J Cell Mol Cardiol 41:633-641, 2006. Abstract.

Bian, W. and L. Tung. Structure-related initiation of reentry by rapid pacing in monolayers of cardiac cells. Circ Res 98:e29-38, 2006. Abstract.

Chang, M. G., L. Tung, R. Sekar, C. Chang, J. Cysyk, P. Dong, E. Marban, and M. R. Abraham. Proarrhythmic potential of mesenchymal stem cell transplantation revealed in an in vitro coculture model. Circ 113:1832-1841, 2006. Abstract.

Bursac, N. and L. Tung. Acceleration of functional reentry by rapid pacing in anisotropic cardiac monolayers: formation of multi-wave functional reentries. Cardiovasc Res 69:381-390, 2006. Abstract.

Abraham, M. R., C. A. Henrikson, L. Tung, M. G. Chang, M. Aon, T. Xue, R. A. Li, B. O'Rourke, and E. Marban. Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation. Circ Res 97:159-67, 2005. Abstract.

Kong, C. R., N. Bursac, and L. Tung. Mechanoelectrical excitation by fluid jets in monolayers of cultured cardiac myocytes. J Appl Physiol 98:2328-2336, 2005. Abstract.

Sharma, V., R. Susil, and L. Tung. Paradoxical loss of excitability with higher intensity pulses during electrical field stimulation of single cardiac cells. Biophys J 88:3038-3049, 2005. Abstract.

Tung, L., N. Bursac, and F. Aguel. Rotors and spiral waves in two dimensions. In: Cardiac Electrophysiology. From Cell to Bedside (Zipes, D. P. and Jalife, J., eds). 4th Ed., W. B. Saunders, Philadelphia, PA, 2004.

Sharma, V. and L. Tung. Ionic currents involved in shock-induced nonlinear changes in transmembrane potential responses of single cardiac cells. Pflugers Arch 449:248-256, 2004. Abstract.

Bursac, N., F. Aguel, and L. Tung. Multi-arm spirals in a two-dimensional cardiac substrate. Proc Natl Acad Sci 101:15530-15534, 2004. Abstract.

Entcheva, E., Y. Kostov, E. Tchernev, and L. Tung. Fluorescence imaginf of electrical activity in cardiac cells. IEEE Trans Biomed Eng 51:333-341, 2004. Abstract.

Riemer, T. L. and L. Tung. Stretch-induced excitaton and action potential changes of single cardiac cells. Prog Biophys Mol Biol 82:97-110, 2003. Abstract.

Iravanian, S., Y. Nabutovsky, C.-R. Kong, S. Saha, N. Bursac and L. Tung. Functional reentry in cultured monolayers of neonatal rat cardiac cells. Am J Physiol Heart Circ Physiol 285:H449-H456, 2003. Abstract. Reprint (pdf) version.

Bursac, N., K. K. Parker, S. Iravanian and L. Tung. Cardiomyocyte cultures with controlled macroscopic anisotropy. A model for functional electrophysiological studies of cardiac muscle. Circ Res 91:e45-e54, 2002. Abstract. Reprint (pdf) version.

Macek Lebar, A., G. C. Troiano, L. Tung and D. Miklavcic. Inter-pulse interval between rectanular voltage pulses affects electroporation threshold of artificial lipid bilayers. IEEE Trans Nanobiosci 1(3):116-120, 2002.

Iravanian, S. and L. Tung. "A novel algorithm for cardiac biosignal filtering based on filtered residue method." IEEE Trans Biomed Eng 49:1310-1317, 2002. Abstract.

Sharma, V. and L. Tung. "Decomposition of field-induced transmembrane potential responses of single cardiac cells." IEEE Trans Biomed Eng 49:1031-1037, 2002. Abstract.

Sharma, V. and L. Tung. "Spatial heterogeneity of transmembrane potential responses of single cardiac cells during electric field stimulation." J Physiol 542:477-492, 2002. Abstract. Reprint (pdf) version.

Sharma, V. and L. Tung. "Effects of uniform electric fields on intracellular calcium transients in single cardiac cells." Am J Physiol Heart Circ Physiol 282:H72-H79, 2002. Abstract. Reprint (pdf) version.

Tung, L. "Response of cardiac myocytes to electrical fields." In: Optical Mapping of Cardiac Excitation and Arrhythmias (D. S. Rosenbaum and J. Jalife, eds.). Futura Publishing Co., Armonk, NY. Chap. 18, 2002. Reprint (pdf) version.

Sharma, V. and L. Tung. "Theoretical and experimental study of sawtooth effect in isolated cardiac cell-pairs." J Cardiovasc Electrophysiol 12:1164-1173, 2001. Abstract. Reprint (pdf) version.

Tung, L. and A. G. Kleber. "Virtual sources associated with linear and curved strands of cardiac cells." Am J Physiol Heart Circ Physiol 279:H1579-H1590, 2000. Abstract. Reprint (pdf) version.

Entcheva, E., S. N. Lu, R. L. Harrison, V. Sharma and L. Tung. "Contact fluorescence imaging (CFI) of reentry in monolayers of cultured neonatal rat ventricular cells." J Cardiovasc Electrophysiol 11:665-676, 2000. Abstract. Reprint (pdf) version.

Riemer, T. L. and L. Tung. "The focal extracellular potential: a means to monitor electrical activity in single frog cardiac myocytes." Am J Physiol 278:H1383-H1394, 2000. Abstract. Reprint (pdf) version.

Sharma, V. and L. Tung. "Transmembrane responses of single guinea pig ventricular cell to uniform electric field stimulus." J Cardiovasc Electrophysiol 10:1296, 1999. Abstract.

Fasciano, R. W. II and L. Tung. "Factors governing mechanical stimulation in the frog heart." Am J Physiol 277:H2311-H2320, 1999. Abstract. Reprint (pdf) version.

Wu, C.-C., R. W. Fasciano, H. Calkins, and L. Tung. "Sequential change in action potential of rabbit epicardium during and following radiofrequency ablation." J Cardiovasc Electrophysiol 10:1252-1261, 1999. Abstract. Reprint (pdf) version.

Troiano, G. C., K. J. Stebe, R. M. Raphael, and L. Tung. "The effects of gramicidin on electroporation of lipid bilayers." Biophys J 76:3150-3157, 1999. Abstract. Reprint (pdf) version.

Cheng, D., L. Tung, and E. A. Sobie. "Nonuniform responses of transmembrane potential during electric field stimulation of single cardiac cells." Am J Physiol 277:H351-H362, 1999. Abstract. Reprint (pdf) version.

Susil, R. C., E. A. Sobie, and L. Tung. "Separation between virtual sources modifies the response of cardiac tissue to field stimulation." J Cardiovasc Electrophysiol 10:715-727, 1999. Abstract. Reprint (pdf) version.

Tung, L., G. C. Troiano, V. Sharma, R. M. Raphael, and K. J. Stebe. "Changes in electroporation thresholds of lipid membranes by surfactants and peptides." Ann NY Acad Sci 888:249-265, 1999. Abstract. Reprint (pdf) version.

Harrison, R.L., B. J. Byrne, and L. Tung. "Electroporation-mediated gene transfer in cardiac tissue." FEBS Letters 435:1-5, 1998. Abstract. Reprint (pdf) version.

Troiano, G. C., L. Tung, V. Sharma, and K. J. Stebe. "The reduction in electroporation voltages by the addition of a surfactant to planar lipid bilayers." Biophys J 75:880-888, 1998. Abstract. Reprint (pdf) version.

Riemer, T. L., E. A. Sobie, and L. Tung. "Stretch-induced changes in excitability and arrhythmogenesis in experimentally-based heart cell models." Am J Physiol 275:H431-H442, 1998. Abstract. Reprint (pdf) version.

Sobie, E. A. and L. Tung. "Post-shock potential gradients and dispersion of repolarization in cells stimulated with monophasic and biphasic waveforms." J Cardiovasc Electrophysiol 9:743-756, 1998. Abstract. Reprint (pdf) version.

Neunlist, M. and L. Tung. "Dose-dependent reduction of cardiac transmembrane potential by high intensity electrical shocks." Am J Physiol 273:H2817-2825, 1997. Abstract. Reprint (pdf) version.

Sobie, E. A., R. C. Susil, and L. Tung. "A generalized activating function for predicting virtual electrodes in cardiac tissue." Biophys J 73:1410-1423, 1997. Abstract. Reprint (pdf) version.

Fishler, M. G., E. A. Sobie, L. Tung, and N. V. Thakor. "Modeling the interaction between propagating cardiac waves and monophasic and biphasic field stimuli: the importance of the induced spatial excitatory response." J Cardiovasc Electrophysiol 7:1183-1196, 1996. Abstract. Reprint (pdf) version.

Sharma, V., K. Stebe, J. C. Murphy, and L. Tung. "Poloxamer 188 decreases susceptibility of artificial lipid membranes to electroporation." Biophys J 71:3229-3241, 1996. Abstract. Reprint (pdf) version.

Fishler, M. G., E. A. Sobie, N. V. Thakor, and L. Tung. "Mechanisms of cardiac cell excitation with premature monophasic and biphasic field stimuli: a model study." Biophys J 70:1347-1362, 1996. Abstract. Reprint (pdf) version.

Tung, L. "Detrimental effects of electrical fields on cardiac muscle." Proc IEEE 84:366-378, 1996. Reprint (pdf) version.

Fishler, M. G., E. A. Sobie, L. Tung, and N. V. Thakor. "Cardiac responses to premature monophasic and biphasic field stimuli." J Electrocardiol (Suppl) 28:174-179, 1995. Abstract. Reprint (pdf) version.

Neunlist, L. and L. Tung. "Spatial distribution of cardiac transmembrane potentials around an extracellular electrode. Dependence on fiber orientation." Biophys J 68:2310-2322, 1995. Abstract. Reprint (pdf) version.

Tung, L. "Electroporation of cardiac cells." In Animal Cell Electroporation and Electrofusion Protocols, edited by J. A. Nickoloff, Humana Press, Totowa, NJ, Chap. 21, pp. 253-271, 1995. Abstract. Reprint (pdf) version.

Tung, L. and S. Zou. "Influence of stretch on excitation threshold of single frog ventricular cells." Exp Physiol 80:221-235, 1995. Abstract. Reprint (pdf) version.

Sharma, V., J. C. Murphy, K. Stebe, and L. Tung. "Poloxamer-188 can reduce conductance and increase stability of artificial lipid membranes during electroporation." In Charge and Field Effects in Biosystems, edited by M. J. Allen, S. F. Cleary, and A. E. Sowers, pp. 398-402. World Scientific, Singapore, 1994.

Neunlist, M. and L. Tung. "Optical recordings of ventricular excitability of frog heart by an extracellular stimulating point electrode." Pacing and Clin Electrophysiol 17:1641-1654, 1994. Abstract. Reprint (pdf) version.

Tung, L., O. Tovar, M. Neunlist, S. K. Jain, and R. J. O'Neill. "Effect of strong electrical shock on cardiac muscle tissue." Ann New York Acad Sci 720:160-175, 1994. Abstract. Reprint (pdf) version.

Tung, L., M. Neunlist, and E. A. Sobie. "Near-field and far-field stimulation of cardiac muscle." In Clinical Applications of Modern Imaging Technology II, edited by L. J. Cerullo, K. S. Heiferman, H. Liu, H. Podbielska, A. O. Wist, L. J. Zamorano, and A. Katzir. SPIE, Vol. 2132, pp. 367-374, 1994. Reprint (pdf) version.

Parikh, S. S., S. Zou, and L. Tung. "Contraction and relaxation of isolated cardiac myocytes of the frog under varying mechanical loads." Circ Res 72: 297-311, 1993. Abstract. Reprint (pdf) version.

Tung, L. "Electrical injury to heart muscle cells." In Electrical Trauma: The Pathophysiology, Manifestations, and Clinical Management, edited by R. C. Lee, E. G. Cravalho, and J. F. Burke, pp. 361-400. University of Cambridge Press, 1992. Reprint (pdf) version.

Tung, L. and J.-R. Borderies. "Analysis of electrical excitation of cardiac muscle cells." Biophys J 63:371-386, 1992. Abstract. Reprint (pdf) version.

Tovar, O. and L. Tung. "Electroporation and recovery of the cardiac cell membrane with rectangular voltage pulses." Am J Physiol 263: H1128-H1136, 1992. Abstract. Reprint (pdf) version.

Neunlist, M., S. Zou, and L. Tung. "Design and use of an 'optrode' for optical recordings of cardiac action potentials." Pflugers Arch 420: 611-617, 1992. Abstract. Reprint (pdf) version.

Tung, L. and S. Parikh. "Cardiac mechanics at the cellular level." J Biomech Eng 113:492-495, 1991. Abstract. Reprint (pdf) version.

Tung, L., N. Sliz, and M. R. Mulligan. "Influence of electrical axis of stimulation on excitation of cardiac myocytes." Circ Res 69:722-730, 1991. Abstract. Reprint (pdf) version.

Luo, C. H. and L. Tung. "Null-balance transducer for isometric force measurements and length control of single heart cells." IEEE Trans Biomed Eng 38: 1165-1174, 1991. Abstract. Reprint (pdf) version.

O'Neill, R. J. and L. Tung. "A cell-attached patch clamp study of the electropermeabilization of amphibian cardiac cells." Biophys J 59:1028-1039, 1991. Abstract. Reprint (pdf) version.

Tovar, O. and L. Tung. "Electroporation of cardiac cell membranes with monophasic or biphasic rectangular pulses." Pacing and Clin Electrophysiol 14, part 2:1887-1892, 1991. Abstract. Reprint (pdf) version.