Selected Publications
David T. Yue, MD PhD

1. Imredy, J.P. and Yue, D.T. 1992. Submicroscopic Ca2+ diffusion mediates inhibitory coupling between individual Ca channels. Neuron 9 :197-207. [PubMed Abstract]
2. Imredy, J.P. and Yue, D.T. 1992. Submicroscopic Ca2+ diffusion mediates inhibitory coupling between individual Ca channels. Neuron 9 :197-207. [PubMed Abstract]
3. Gingrich, K.J., Beardsley, D.T., and Yue, D.T. 1993. Ultra-deep blockade of Na channels by a quaternary ammonium ion: Catalysis by a transition-intermediate state? J. Physiol. (Lond.) 471 :319-341. [PubMed Abstract]
4. Yue, D.T. 1993. Bridging the gap between anomalous Na channel molecules and aberrant physiology. Biophys. J. 65 :13-14.
5. Herzig, S., Patil, P., Neumann, J., Staschen, C-M., and Yue, D.T. 1993. Mechanisms of beta-adrenergic stimulation of cardiac Ca2+ channels revealed by discrete-time Markov analysis of slow gating. Biophys. J. 65 :1599-1612. [PubMed Abstract]
6. Imredy, J.P., and Yue, D.T. 1994. Mechanism of Ca-sensitive inactivation of L-type Ca channels. Neuron 12 :1301-1318. [PubMed Abstract]
7. Dobrunz, L.E., Backx, P.H., and Yue, D.T. 1995. Steady-state [Ca2+]i-force relationship in intact twitching cardiac muscle: direct evidence for modulation by isoproterenol and EMD 53 998. Biophys. J . 69 :189-201. [PubMed Abstract]
8. Wiechen, K., Yue, D.T. , and Herzig, S.W. 1995. Two distinct functional effects of protein phosphatase inhibitors on guinea-pig cardiac L-type Ca channels. J. Physiol. (Lond.) , 484 :583-592. [PubMed Abstract]
9. de Leon, M., Wang, Y., Jones, L., Perez-Reyes, E., Wei, X., Soong, T.W., Snutch, T.P., and Yue, D.T. 1995. Essential Ca2+-binding motif for Ca2+-sensitive inactivation of L-type Ca2+ channels. Science 270 :1502-1506. [PubMed Abstract]
10. Bourinet, E., Zamponi, G.W., Stea, A., Soong, T.W., Lewis, B.A., Jones, L.P., Yue, D.T. , and Snutch, T.P. 1996. The a 1E calcium channel exhibits permeation properties similar to low voltage-activated calcium channels. J. Neurosci. 16 :4983-4993. [PubMed Abstract]
11. Patil, P.G., de Leon, M., Reed, R.R., Dubel, S., Snutch, T.P., and Yue, D.T. 1996. Elementary events underlying voltage-dependent G-protein inhibition of N-type calcium channels. Biophys. J. 71 :2509-2521. [PubMed Abstract]
12. Jones, L.P., Patil, P.G., Snutch, T.P., and Yue, D.T. 1997. G-protein modulation of N-type calcium channel gating current. J. Physiol. (Lond.) 498 :601-610. [PubMed Abstract]
13. Brody, D.L., Patil, P.G., Mulle, J.G., Snutch, T.P., and Yue, D.T. (1997). Bursts of action potential waveforms relieve G-protein inhibition of recombinant P/Q-type Ca2+ channels. J. Physiol. (Lond.) 499 :637-644. [PubMed Abstract]
14. Cai, D.M., Mulle, J.G., and Yue, D.T. (1997). Inhibition of recombinant Ca2+ channels by benzothiazepines and phenylalkylamines: class-specific pharmacology and underlying molecular determinants. Molecular Pharmacol 51 :872-881. [PubMed Abstract]
15. Yue D.T. 1997. Quenching the spark in the heart. Science 1997 276:755-6.
16. Patil, P.G., Brody, D.L., and Yue, D.T. 1998. Preferential closed-state inactivation of neuronal calcium channels. Neuron 20 :1027-1038. [PubMed Abstract]
17. Jones, L.P., Wei, S-.K., and Yue, D.T. 1998. Mechanism of axuiliary-subunit modulation of neuronal a 1E calcium channels. J. Gen. Physiol. 112 :125-143. [PubMed Abstract]
18. Peterson1 , B. Z., C. D. DeMaria1 , J. P. Adelman, and Yue, D.T . 1999. Calmodulin is the Ca2+ sensor for Ca2+-dependent inactivation of L-type calcium channels. Neuron. 22 : 549-58. 1co-first authors. [PubMed Abstract]
19. Jones, L. P., C. D. DeMaria, and Yue, D. T. 1999. N-Type calcium channel inactivation probed by gating-current analysis. Biophys J. 76 : 2530-52. [PubMed Abstract]
20. Wei, S.K., Colecraft, H.M., DeMaria, C.D., Peterson, B.Z., Zhang, R., Kohout, T.A., Rogers, T.B., and Yue, D.T. 2000.  Calcium-channel modulation by recombinant auxiliary beta subunits expressed in young adult heart cells.  Circ. Res. 86 :175-184.
21. Brody, D.L., and Yue, D.T. 2000.  Relief of G-protein inhibition of calcium ­ channels and short-term synaptic facilitation in cultured hippocampal neurons.  J. Neurosci. 20 :889-898.
22. Peterson, B.Z., Lee, J.S., Mulle, J.G., Wang, Y., de Leon, M., and Yue, D.T.   2000.  Critical determinants of Ca2+-dependent inactivation within an EF-hand motif of L-type Ca2+ channels.  Biophys. J. 78 :1906-1920.
23. Colecraft, H.M., Patil, P.G., and Yue, D.T.  2000.  Differential occurrence of reluctant openings in G-protein-inhibited N- and P/Q-type calcium channels.  J. Gen. Physiol. 115 :175-192.
24. Brody, D.L., and Yue, D.T.   2000.  Release-independent short-term synaptic depression in cultured hippocampal neurons.  J. Neurosci. 20 :2480-2494.
25. Colecraft, H.M., Brody, D.L., and Yue, D.T.   2001.  G-protein inhibition of N- and P/Q-type calcium channels: distinctive elementary mechanisms and their functional impact.  J. Neurosci. 21 :1137-1147.
26. DeMaria, C.D., Soong, T.W., Alseikhan, B.A., Alvania, R.S., and Yue, D.T.   2001.  Calmodulin bifurcates the local Ca2+ signal that modulates P/Q-type Ca2+ channels.  Nature 411 :484-489.
27. Erickson, M.G., Alseikhan, B.A., Peterson, B.Z., and Yue, D.T.   2001.  Preassociation of calmodulin with voltage-gated Ca2+ channels revealed by FRET in single living cells.  Neuron 31 :973-985.  
28. Colecraft, H.M., Alseikhan, B.A., Takahashi, S.X., Chaudhuri, D., Mittman, S., Yegnasubramanian, V., Alvania, R.S., Johns, D.C., Marban, E., and Yue, D.T.   2002.  Novel functional properties of Ca2+ channel beta subunits revealed by their expression in adult rat heart cells.  J. Physiol. 541 :435-52.
29. Deschenes, I., Neyroud, N., Di Silvestre, D., Marban, E., Yue, D.T. , and Tomaselli, G.F.  2002.  Isoform-specific modulation of voltage-gated Na+ channels by calmodulin. Circ. Res. 90 :E49-57.
30. Soong, T.W., DeMaria, C.D., Alvania, R.S., Zweifel, L.S., Liang, M.C., Mittman, S., Agnew, W.S., and Yue, D.T. 2002. Systematic identification of splice variants in human P/Q-type channel a 2.1 subunits: Implications for current density and Ca2+-dependent inactivation.  J. Neurosci.  22 :10142-10152.
31. Alseikhan, B.A., DeMaria, C.D., Colecraft, H.M., and Yue, D.T.   2002.  Engineered calmodulins reveal unexpected eminence of Ca channel inactivation in controlling heart excitation.  Proc. Natl. Acad. Sci. U.S.A.   99 :17185-17190.
32. Agler, H.L., Evans, J. Colecraft, H.M., and Yue, D.T. 2003. Custom distinctions in the interaction of G-protein b subunits with N-type (Ca V 2.2) versus P/Q-type (Ca V 2.1) calcium channels. J. Gen. Physiol. 121 :495-510.
33. Erickson, M.G., Moon, D.L., and Yue, D.T. 2003. DsRed as a potential FRET partner with CFP and GFP. Biophys. J. 85 :599-611.
34. Erickson, M.G., Liang, H., Mori, M.X., and Yue, D.T. 2003. FRET two-hybrid mapping reveals function and location of L-type Ca2+ channel CaM preassociation. Neuron 39 :97-107.
35. Evans, J., and Yue, D.T. 2003. New turf for CFP/YFP FRET imaging of membrane signaling molecules. Neuron 38 :145-152.
36. Liang, H., DeMaria, C.D., Erickson, M.G., Mori, M.X., Alseikhan, B.A., and Yue, D.T. 2003. Unified mechanisms of Ca2+ regulation across the Ca2+ channel family. Neuron 39 :951-960.
37. Mori, M.X., Erickson, M.G., and Yue, D.T. 2004. Functional stoichiometry and local enrichment of calmodulin interacting with Ca2+ channels. Science | Full Text 304 :432-5 (see Perspectives in Science 304 :394-5; and Highlights in Nature Reviews Neuroscience 5 :432 ).
38.

Chaudhuri, D., Chang, S.Y., DeMaria, C.D., Alvania, R.S., Soong, T.W., and Yue, D.T. (2004). Alternative splicing as a molecular switch for Ca2+/calmodulin-dependent facilitation of P/Q-type Ca2+ channels. J. Neurosci. 24:6334-6342..

39. Tang, Z.Z., Liang, M.C., Lu, S., Yu, D., Yu, C.Y., Yue, D.T., and Soong, T.W. (2004).  Transcript scanning reveals novel and extensive splice variations in human l-type voltage-gated calcium channel, Cav1.2 alpha1 subunit.  J Biol Chem. 279:44335-44443.
40. Agler, H.L., Evans, J., Tay, L.H., Anderson, M.J., Colecraft, H.M., and Yue, D.T. (2005).  G-protein gated inhibitory module of N-type Ca channels. Neuron 46:891-904.
41.

Chaudhuri, C., Alseikhan, B.A., Chang, S.Y., Soong, T.W., and Yue, D.T.  (2005).  Developmental activation of calmodulin-dependent facilitation of cerebellar P-type Ca2+ current. J. Neurosci.  25:8282-8294.
42. Takahashi, S.X., Miriyala, J., Tay, L.H., Yue, D.T., and Colecraft, H.M. (2005).  A CaVß SH3/guanylate kinase domain interaction regulates multiple properties of voltage-gated Ca2+ Channels. J. Gen. Physiol. 126:365-377.
43.

Liao, P., Yong, T.F., Liang, M.C., Yue, D.T., Soong, T.W. (2005).  Splicing for alternative structures of CaV1.2 Ca2+ channels in cardiac and smooth muscles.  Cardiovasc Res. 68:197-203.
   
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